SUVN-G3031 dihydrochloride ( SUVN-G 3031 )

Catalog No. M11646 CAS No. 1394808-20-8

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Datasheet

HNMR

HPLC

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Product Name

SUVN-G3031 dihydrochloride
Note

Research use only, not for human use.
Brief Description

SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
Description

SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 μM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo.Parkinson Disease Phase 1 Clinical
Synonyms

SUVN-G 3031
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

Neurological Disease
Indication

Parkinson Disease

CAS Number

1394808-20-8
Formula Weight

446.41
Molecular Formula

C21H33Cl2N3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CC(C1)N2CCC(CC2)OC3=CC=C(C=C3)NC(=O)CN4CCOCC4.Cl.Cl
Chemical Name

N-[4-(l-Cyclobutylpiperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride

1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280.

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