SUVN-G3031 dihydrochloride

CAS No. 1394808-20-8

SUVN-G3031 dihydrochloride ( SUVN-G 3031 )

Catalog No. M11646 CAS No. 1394808-20-8

SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 262 Get Quote
50MG 1458 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
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Biological Information

  • Product Name
    SUVN-G3031 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
  • Description
    SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 μM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo.Parkinson Disease Phase 1 Clinical
  • Synonyms
    SUVN-G 3031
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Parkinson Disease

Chemical Information

  • CAS Number
    1394808-20-8
  • Formula Weight
    446.41
  • Molecular Formula
    C21H33Cl2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CC(C1)N2CCC(CC2)OC3=CC=C(C=C3)NC(=O)CN4CCOCC4.Cl.Cl
  • Chemical Name
    N-[4-(l-Cyclobutylpiperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280.
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